Proteinase 3 antibodies (anti-PR3)

Proteinase 3 (PR3) is the main antigen for cANCA, anti-neutrophil cytoplasmic antibodies directed against the cytoplasm. PR3 antibodies have a strong connection to granulomatosis with polyangiitis (GPA), formerly known as Wegener’s granulomatosis. Up to 80% of patients – and possibly more of those with active disease – have these antibodies.

Granulomatosis with polyangiitis is a type of vasculitis, an autoimmune inflammation of the blood vessels, which typically affects the sinuses, nose, and throat; the lungs; and the kidneys.

Besides indirect immunofluorescence assays, immunoblots and ELISA tests for ANCA and anti-PR3, a biopsy of the affected organ is often performed to confirm the diagnosis.

 

ANCA tests offered by ORGENTEC Diagnostika

ELISA/Alegria^®:

ANCAcombi (ORG 530)
Anti-PR3 (cANCA) (ORG 518, ORG 218)
Anti-PR3 hs (high sensitive) (ORG 618, ORG 318)

Immunoblot:

ANCA-3-Line (ORG 789)