SS-B antibodies (anti-La)

SS-B/La antibodies are found primarily in patients suffering from Sjögren’s syndrome (up to 70% in primary Sjögren’s syndrome, up to 50% in secondary Sjögren’s syndrome). For systemic lupus erythematosus, SS-B antibodies are detectable in up to 25% of patients and provide some indications of the prognosis of the disease. Mostly, they are found together with SS-A antibodies; if these autoantibodies are absent, they only appear infrequently.

Testing for SS-B antibodies is indicated for patients with signs and symptoms of a connective tissue disease and in whom the test for antinuclear antibodies (ANA) is positive, especially when symptoms are consistent with Sjögren’s syndrome or lupus erythematosus. In addition to it, in asymptomatic people suspected of having Sjögren’s syndrome, SS-B antibodies can clarify the full picture of the disease.

The SS-B/La antigen is one of four autoantigens commonly referred to as extractable nuclear antigens (ENA). The other ENAs are RNP, SS-A/Ro, and Sm.

 

Tests offered by ORGENTEC Diagnostika

ELISA/Alegria®:

Anti-SS-B (ORG 509, ORG 209)
ANAcombi (ORG 539)
ENAcombi (ORG 514)
ENA-4-Profile (ORG 544)
ENA-6-Profile (ORG 546)

Immunblots:

ANA-9-Line (ORG 710-08, ORG 710-16)
Nucleo-9-Line (ORG 711-08, ORG 711-16)

IFA:

Anti-Nuclear Antibodies HEp-2 (ANA-HEp-2) (ORG 870)

 

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