Narcolepsy

Narcolepsy is characterised by chronic excessive daytime sleepiness, often with sudden loss of muscle tone. Other symptoms include sleep paralysis and hallucinations. The cause of the disorder is unknown, but narcolepsy may be an autoimmune disease.

Children of patients with narcolepsy have a 40-fold increased risk, suggesting a genetic cause. Narcolepsy is strongly associated with specific HLA haplotypes. However, studies show low concordance in twins (25%). Environmental factors may have a prominent role, triggering the disease. As the neuropeptide hypocretin-1 is deficient in most human patients, the cause may be a HLA-associated autoimmune destruction of hypocretin-containing neurons in the lateral hypothalamus.

 

 

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this: